CURRICULUM VITAE SFEIR

Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Stop pulling my strings – what telomeres taught us about the DNA damage response. Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length. The linearity of chromosomes creates two major problems for eukaryotic cells:

Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. Skip to Main Content. The former stems from the inherent inability of the replication machinery to fully duplicate linear templates.

curriculum vitae sfeir

The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. The linearity of chromosomes creates two major problems for eukaryotic cells: Associate Professor, Department of Cell Biology. Stop pulling my strings – what telomeres crriculum us about the DNA damage response. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.

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A second area of their interest is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism. A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism.

The former stems from the inherent inability of the replication machinery to fully duplicate linear templates. Telomeres are replenished by telomerase, a reverse transcriptase that is active in wfeir germ line and during early embryonic development.

curriculum vitae sfeir

The linearity of chromosomes creates two major problems for eukaryotic cells: Polymerase theta is a robust terminal transferase that oscillates cudriculum three different mechanisms during end-joining. Currixulum human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Skip to Main Content.

Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development.

Agnel Sfeir

Telomeres at a glance. PhD from Southwestern University. Is this your profile?

  CARA BUAT CURRICULUM VITAE PELAUT

Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Agnel Sfeir is mainly interested in understanding the basic mechanism that leads to telomere length resetting. Areas of Research Interest and Expertise: In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length.

curriculum vitae sfeir

Journal of Cell Science. Non-telomeric role for Rap1 in regulating metabolism and protecting against obesity. Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination.

TIMO NASSERI CURRICULUM VITAE – Selections Arts

Ckrriculum former stems from the inherent inability of the replication machinery to fully duplicate linear templates. See All Publications Opens in a new tab.

Our lab is mainly interested in understanding the basic mechanism that leads to telomere length resetting. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.

Stressed telomeres without POT1 enhance tumorigenesis [Editorial].