This was observed in related studies within the East African region 7 , Antigen retrieval is carried out to increase the sensitivity of the technique. Are solitary thyroid nodules more likely to be malignant? Fine-needle aspiration of the thyroid. The aim of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard. Fine needle aspiration cytology of thyroid nodules at Kenyatta National Hospital, Nairobi. We were unable to achieve the estimated sample size within the study period.
The false positive rate was Epidemiology of thyroid diseases in Africa. Aim The objective of this study is to determine the accuracy of manual FNAC for the diagnosis of histologically proven thyroid malignancy in a community pathology practice over a year period. Am J Clin Pathol. In this study, a review of cases led to 13 5.
It is recommended as the first line investigation for the diagnosis of solitary thyroid nodule. Results A total of 99 patients were enrolled theis prospective and 54 retrospective. Commonest malignancy detected was papillary carcinoma in 12 patients. The results were quite similar to the results of a study conducted by Herraiz et al.
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
The research was conducted at the department of Pathology, King Edward Medical University, in association with other teaching institutions of Lahore from June to July The difference could probably be attributed to the fact that a significant proportion of long standing multinodular goiter in areas endemic for iodine deficiency tend to undergo malignant transformation American Journal of Clinical Pathology. Indexed in Web of Science.
This provided rigid support to tissue blocks so that it was easy to cut them into thin sections. The thyroid nodule was immobilised and stabilised between the index finger and the thumb of the left hand.
Discussion The aim of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard.
The median duration of symptoms was weeks IQR — The authors appreciate the co-operation of patients who participated in this study, the staff from the records section of Pathology Department for retrieving patients’ data and Dr. Rom J Morphol Embryol. Nevertheless no noteworthy association between size and duration of growth and the presence of malignancy was found.
Patients who underwent clinical and laboratory evaluation and thyroidectomy at Mulago National Referral hospital and the Pathology department of Makerere University College of Health Sciences were consecutively recruited over a four months period.
Distinct effects on splicing of two monoclonal antibodies directed against the amino-terminal domain of galectin Open thesia a separate window. Table 2 Baseline clinical characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm.
It is often used as the initial screening test for diagnosis of thyroid nodules [ 1 ].
Indian journal of endocrinology and metabolism. The sensitivity and specificity for detecting malignancy on FNAC was A 23Fr gauge needle attached to a 10 ml syringe was inserted into the nodule.
It is a challenge to differentiate between follicular adenoma and follicular carcinoma without histology. Study design This was a retrospective study.
FNAC is considered the gold standard diagnostic test in the evaluation of a thyroid nodule, and other tests like ultrasound and nuclear scan should be used in conjunction with FNAC. Table 1 Social demographic characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm.
Journal of Thyroid Research
The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were Four of five cases of anaplastic carcinoma had yhyroid biopsy and were diagnosed solely on FNAC.
The aim of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard. East African Medical Journal. There were 60 patients in our study with a mean age of This is in accordance with the study by Dorairajan and Jayashree [ 7 ].
The proportion of patients with malignancy was Biopsy maneouvre was terminated when fluid appeared in the hub of the needle. There appears to be a changing trend towards the frequent occurrence of papillary thyroid carcinoma PTC compared to follicular thyroid carcinoma FTC.
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